Massimo Fioranelli
 
 
Mater Dei - Via A. Bertoloni, 34 - 00197 Roma - Tel. + 39 6 80220.1 - Fax +39 6 8084556 Italiano  Italiano   English  English 
24/02/2016 The Dangers of Arterial Plaque
11/01/2016 Carnosine
11/01/2016 Discordance Between Apolipoprotein B and LDL-Cholesterol in Young Adults Predicts Coronary Artery Calcification The CARDIA Study
08/01/2016 Minimum Vitamin D Dose Inadequate For Overweight African Americans
06/01/2016 Increased Vitamin C Linked To Reduced Risk Of Early Mortality
06/01/2016 Depression Higher In Men With Borderline Testosterone Levels
06/01/2016 Resveratrol, Quercetin Could Improve Safety Of Cancer Drug






 




Per visualizzare il video una volta aperto il portale di Marconi Channel, cliccare su Scienza & Tecnologia quindi selezioanre il video dalla playlist.


Per visualizzare il video una volta aperto il portale di Marconi Channel, cliccare su Scienza & Tecnologia quindi selezioanre il video dalla playlist.








Il Progetto Health Phone ® ha lo scopo di tutelare la salute del cittadino, mediante un sistema di georeferenziazione ed un cardiofrequenzimetro, il Sistema Health Phone ® è in grado di effettuare chiamate immediate di pronto soccorso al 118, e di inviare dati alle persone più prossime con indicazioni di pronto intervento.
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Il Progetto Universal Guide ® propone la realizzazione di una guida universale da implementare su sistemi smart-phone o palmari. Attraverso l’integrazione di più sistemi di georeferenziazione, interna (RFID, Wi-Fi) ed esterna (GPS, Wi-Fi), la Universal Guide ® sarà in grado di guidare l’utente, anche non normodotato, attraverso il rispetto dei principi sull’accessibilità, all’interno di un museo, di un edificio pubblico, di un ospedale.
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GRAZIE
ALLA TC CORONARICA,
IL CUORE “PARLA”
Dopo 30 anni l’era della coronarografia sembra avviarsi alla sua conclusione.
E si allontana anche l’incubo delle radiazioni. Adesso c’è una tecnica, TC coronarica, disponibile anche a Roma, non invasiva, finalmente non rischiosa, molto più affidabile, in grado di scoprire quello che fino ad oggi la coronarografia non riusciva a “vedere”.
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The SYNTAX Score is a unique tool to score complexity of coronary artery disease.
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If you are healthy and without diabetes, the Reynolds Risk Score is designed to predict your risk of having a future heart attack, stroke, or other major heart disease in the next 10 years.
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Salute/ Prevenzione infarto,
nuova strategia diagnostica
Mater Dei
Roma - 8 novembre 2010

Gli esami dicono che tutto e' a posto ma poco dopo l'infarto puo' arrivare. Oggi è possibile intervenire precocemente, prima che l'infarto arrivi, grazie ad una strategia diagnostica altamente innovativa messa a punto a Roma dall'équipe di Massimo Fioranelli e Paolo Pavone della Clinica Mater Dei. Un 'Modello diagnostico integrato' che ...











RAI - Cardiologia,
le novità diagnostiche

A Tg1 online, il professor Fioranelli, dell'Università Gugliemo Marconi, ha risposto alle domande degli utenti. Ha moderato Manuela Lucchini.

RAI - 26/10/2011




RAI - Storie di salute
Nel talk-show condotto da Luana Ravegnini si parlerà di "malattie cardiovascolari" con il Professor Fioranelli ma anche di "sovrappeso e diete" con il Professor Ticca.

RAI - 19 gennaio 2009



FUMO E INFARTO
Fumare di meno fa bene al cuore: da quando è in vigore la legge antifumo in Italia sono diminuiti anche gli infarti.
Tg1 - 13 febbraio 2008



NUOVE FRONTIERE
DELLA MEDICINA
Alcuni ricercatori americani hanno messo a punto una tecnica di rigenerazione dei tessuti del cuore attraverso le staminali.
Tg1 - 14 gennaio 2008



NOVITA' PER IL CUORE
Ricercatori britannici hanno scoperto farmaci capaci di limitare i danni provocati dall'infarto o dall'ipertensione al cuore degli anziani.
Tg1 - 5 settembre 2006







 


 

 


Per iscrizioni:
Segreteria Scientifica A.M.I.O.T - Tel. 02/89072755
Email: didattica@medibio.it

 


Info: www.sipnei.it
www.sipneipiemonte.altervista.org

 

 

 

 

 

 

 

Lavora con Noi: chi fosse interessato ad avere una collaborazione professionale puo’ inviare il proprio curriculum a: segreteriamassimofioranelli@gmail.com.





 02/06/2016  Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease   Several sequence variants are known to have effects on serum levels of non–highdensity lipoprotein (HDL) cholesterol that alter the risk of coronary artery disease. We sequenced the genomes of 2636 Icelanders and found variants that we then imputed into the genomes of approximately 398,000 Icelanders. We tested for association between these imputed variants and non-HDL cholesterol levels in 119,146 samples. We then performed replication testing in two populations of European descent. We assessed the effects of an implicated loss-of-function variant on the risk of coronary artery disease in 42,524 case patients and 249,414 controls from five European ancestry populations. An augmented set of genomes was screened for additional loss-of-function variants in a target gene. We evaluated the effect of an implicated variant on protein stability. We found a rare noncoding 12-base-pair (bp) deletion (del12) in intron 4 of ASGR1, which encodes a subunit of the asialoglycoprotein receptor, a lectin that plays a role in the homeostasis of circulating glycoproteins. The del12 mutation activates a cryptic splice site, leading to a frameshift mutation and a premature stop codon that renders a truncated protein prone to degradation. Heterozygous carriers of the mutation (1 in 120 persons in our study population) had a lower level of non-HDL cholesterol than noncarriers, a difference of 15.3 mg per deciliter (0.40 mmol per liter) (P=1.0×10−16), and a lower risk of coronary artery disease (by 34%; 95% confidence interval, 21 to 45; P=4.0×10−6). In a larger set of sequenced samples from Icelanders, we found another loss-of-function ASGR1 variant (p.W158X, carried by 1 in 1850 persons) that was also associated with lower levels of non-HDL cholesterol (P=1.8×10−3). CONCLUSIONS ASGR1 haploinsufficiency was associated with reduced levels of non-HDL cholesterol and a reduced risk of coronary artery disease. (n engl j med 374;22June 2, 2016)

 02/06/2016   Long QT syndrome mutations and sudden unexpected death in epilepsy (May 2016)   Sudden unexpected death in epilepsy (SUDEP) accounts for up to one-third of premature deaths in patients with epilepsy, and the pathophysiologic mechanisms are not well defined. A new study suggests that some patients may be predisposed to SUDEP due to congenital long QT syndrome (LQTS). In a study of 61 SUDEP cases for which whole blood was available at autopsy, exome sequencing identified pathogenic LQTS mutations in four patients [2]. An additional nine patients had candidate pathogenic variants in dominant cardiac arrhythmia genes. Prospective studies are needed to determine whether electrocardiogram monitoring or other strategies can identify patients at risk for SUDEP and lead to interventions to reduce risk in patients with epilepsy

 26/04/2016  Low Vitamin D Levels Linked To Greater Premature Mortality Risk   A study reported in the British Medical Journalhas uncovered an association between genetically low vitamin D levels and an increased risk of mortality over follow-up among Danish men and women. The investigation included 95,766 participants in three studies. Over the study’s median follow-up time of up to 19.1 years, 10,349 deaths occurred. After evaluating the association between 25-hydroxyvitamin D levels and mortality over the follow-up period, the researchers analyzed the relationship between genotypes that decrease plasma vitamin D and the risk of mortality. “We can see that genes associated with low vitamin D levels involve an increased mortality rate of 30%and, more specifically, a 40%higher risk of cancer-related deaths,” reported lead author Shoaib Afzal. “An important factor in our study is that we have established a causal relationship.” *Br Med J. 2014 Nov 19.

 17/04/2016   DNA Damage May Be A Marker Of Insufficient Zinc Status   A trial reported in Nutrition Researchfound a protective effect for zinc supplementation against DNA strand breaks.* This type of genetic damage is caused primarily by reactive oxygen species and can lead to further damage and consequent disorders if not repaired. The study included 40 Ethiopian women believed to be of low zinc status due to decreased meat intake and high dietary phytate levels, which reduce zinc absorption. Plasma zinc levels were measured in blood samples collected at the beginning of the study. The women were given 20 mgzinc or a placebo daily for 17 days. Comet assay of intracellular DNA strand breaks was conducted in cells collected at the beginning and end of the trial. By the end of the study, comet tail measurement of DNA strand breaks decreased from an average of 39.7to 30.0in the supplemented group. DNA repairis an essential element of longevity and a number of nutrients that health conscious people supplement with today have been shown to help facilitate DNA repair. Zinc levels and DNA damage, the comet assay, a method that measures DNA strand breaks in cells, may represent a sensitive functional tool to assess response to zinc supplementation.” * Nutr Res. 2015 Jan;35(1):49-55. From LifeExtension

 16/04/2016   Mediterranean Diet Associated With Longer Telomeres   According to an article published in the British Medical Journaland widely reported by CNN in early December, those who regularly eat a Mediterranean diet rich in polyphenols and anti-inflammatory compounds have longer telomeres and may live longer than those who don’t.* Researchers utilized data from 4,676 middle-aged participants in the ongoing Nurses’ Health Study, which began enrolling subjects in 1976. Dietary questionnaires completed in 1980 were scored for adherence to a Mediterranean diet, which is characterized by a high intake of vegetables, fruits, nuts, legumes, grains, and olive oil. Blood samples collected from 1989 to 1990 were analyzed for white blood cell telomere length. Telomeres, which cap the ends of chromosomes, get shorter every time a cell divides, so their length is thought to be a measure of a cell’s aging. Stress and inflammation may also shorten people’s telomeres, the researchers said in the study. “Our findings showed that healthy eating, overall, was associated with longer telomeres,” reported lead author Marta Crous-Bou, a postdoctoral fellow in the Channing Division of Network Medicine. “However, the strongest association was observed among women who adhered to the Mediterranean diet.” Telomeres have been the subject of a significant amount of recent research. Longer telomeres have been associated with a reduced risk of chronic diseases and increased life span. LifeExtension (BMJ. 2014;349:g667)

 10/04/2016  Zucca Amara per il diabete   La Momordica charantia, conosciuta anche come bitter melon (o zucca amara) è una pianta rampicante tropicale e sub-tropicale della famiglia Cucurbitaceae, particolarmente diffusa in Asia ed Africa per i frutti commestibili. Nella medicina ayurvedica il suo utilizzo è indicato per varie problematiche quali costipazione, infiammazioni ed infezioni, patologie respiratorie. Ad oggi è invece nota soprattutto per il trattamento dell'iperglicemia: delle 228 specie chimiche isolate infatti alcune hanno mostrato significativi effetti ipoglicemizzanti. È il caso dei momordicosidi, in grado di stimolare la traslocazione del trasportatore GLUT4 alla membrana negli adiposità, e di momordicilina e momordenolo, che inibiscono invece una glicogeno sintesi chinasi (GSK-3); il polipeptide-p infine ha dimostrato effetti ipoglicemizzanti in vivo. Un altro importante componente attivo recentemente scoperto è un polipeptide in grado di attivare il recettore dell'insulina, detto mcIRBP, il cui meccanismo d'azione è stato oggi pienamente delucidato. La frazione attiva di questo peptide è il residuo di 19 aminoacidi carbossiterminale, caratterizzato da una struttura beta-hairpin in grado di interagire con il recettore insulinico (IR) ed incrementarne la sensibilità all'insulina. Si ottiene così sia -in vitro- un aumento dell'intake di insulina da parte di cellule adipose in coltura, sia -in vivo- una aumentata clearance del glucosio ed una incrementata tolleranza in topi diabetici di tipo 1 e di tipo 2. Studi in database proteomici hanno infine rivelato che motivi simili per sequenza e struttura tridimensionale sono contenuti in peptidi presenti in molte specie vegetali quali zucca, riso, pompelmo, vite e rosmarino. Lo studio, ancorché precilinico, è molto interessante non solo per la buona qualità metodologica espressa ma anche per il potenziale impatto su una delle patologie più diffuse al mondo, che affligge 387 milioni di persone e causa quasi 5 milioni di morti l'anno causando inoltre ingentissime spese per qualsiasi sistema sanitario nazionale. Confermando questi studi sull'uomo si potrebbe infatti produrre una nuova classe farmaceutica dal basso costo e dagli scarsissimi effetti collaterali. Lo,H., et al. Food Chem. 2016 Aug 1;204:298-305. doi: 10.1016/j.foodchem.2016.02.135. ( Fonte : Fitoterapia 33)

 02/04/2016   Estratto di Cipolla e Colesterolo   Da uno studio coreano dell’ottobre 2013 è emersa una notevole capacità dell’estratto di buccia di cipolla di ridurre l’ossidazione dei grassi nel sangue. Uno dei principali motivi che rende il colesterolo tanto pericoloso è determinato dal rischio di ossidazione delle placche all’interno dei vasi sanguigni. Un regolare consumo di frutta e verdura ad elevato contenuti di antiossidanti (polifenoli) è stato già in passato provato essere in grado di prevenire molte malattie cardiovascolari. Nel corso dello studio è emerso che la somministrazione di estratto di buccia di cipolle per due settimane il livello di colesterolo totale era significativamente diminuito. Le potenzialità emerse dallo studio dell’estratto sono evidenti: miglior profilo lipidico complessivo e mantenimento dei livelli dei principali antiossidanti nel sangue (tra i quali anche coenzima Q10). Bibliografia: Nutr Res Pract. 2013 Oct;7(5):373-9. doi: 10.4162/nrp.2013.7.5.373. Epub 2013 Oct 1.Effect of onion peel extract supplementation on the lipid profile and antioxidativeDa Vladimiro Colombi Fonte: www.naturessere.it

 18/03/2016  Datteri e Colesterolo  Il dattero è un frutto meraviglioso, che porta benefici enormi al nostro organismo. È, infatti, un potente antinfiammatorio che può risultare utile per abbassare il colesterolo. Leggiamo su Greenme.it: “Sono ricchi di ferro, vitamine e sali minerali. Contengono zuccheri naturali che li rendono adatti per dolcificare alimenti e bevande. Il consumo regolare di datteri può contribuire ad abbassare il colesterolo. Sono inoltre un vero e proprio antinfiammatorio naturale adatto in caso di raffreddore e irritazioni alle vie respiratorie“. Nello specifico, “i datteri non contengono colesterolo e presentano una scarsa quantità di grassi. Rappresentano una buona fonte di fibre vegetali e di vitamine del gruppo B, come la vitamina B1, B2, B3 e B5. Contengono inoltre vitamina C. Contribuiscono al buon funzionamento del sistema digestivo, per via della presenza di fibre sia solubili che insolubili e di differenti tipologie di amminoacidi“. I datteri sono, per di più, un’ottima fonte di energia e un modo per spezzare la fame: “Sono una fonte di energia immediatamente a disposizione dell’organismo, per via del loro contenuto di zuccheri naturali, come il fruttosio. Per questo motivo potrete utilizzarli per preparare una colazione energetica, nei frullati di frutta o spezzettati in abbinamento con frutta e cereali per creare un muesli casalingo. Rappresentano uno spezzafame salutare, soprattutto se si fa attenzione ad evitare i datteri conservati con additivi artificiali e sciroppo di glucosio. Inoltre sono una buona fonte di potassio e risultano allo stesso tempo poveri di sodio. Ciò li rende utili per favorire il buon funzionamento del cuore e della circolazione del sangue“. E sono anche un ottimo rimedio per il raffreddore: “In caso di raffreddore, per trovare sollievo, potrete preparare un decotto di datteri, come suggerito sul nostro Forum. Vi serviranno 100 grammi di datteri secchi e mezzo litro d’acqua. E’ sufficiente bollire i datteri per qualche minuto nell’acqua, filtrare e dolcificare a piacere. Poi potrete mangiare i datteri, oppure utilizzarli nelle vostre ricette in sostituzione dello zucchero“. Fonte: http://www.lafucina.it/2014/12/16/dattero/

 24/02/2016   The Dangers of Arterial Plaque Cardiovascular disease remains the leading cause of death among older adults.  Atherosclerosis, the thickening and narrowing of arteries, is the cumulative result of elevated cholesterol, chronic inflammation, and other factors. It leads to coronary heart disease (heart attack), stroke, and peripheral vascular disease.In recent years, we’ve developed a vastly more sophisticated understanding of the processes leading up to devastating arterial blockage by plaque lesions. Their foundation begins even before the teen years with the development of so-called fatty streaks, or regions of increased fat in the walls of arteries. At first, the small damaged fatty streak areas trigger a “healing” response, as if the streak areas were a wound, attracting inflammatory cells that ingest and store excess fats. Eventually, arterial plaquebegins to take shape as a core of fats develops outside of inflammatory cells. These plaques become less stable over time, making them more vulnerable to rupture, which leads to heart attacks and strokes. Anything we can do to slow the progression of early fatty deposits to plaque lesions is beneficial, and anything we can do stabilize these plaques makes the risk of a sudden catastrophic heart attack or stroke much less likely. Two particular supplements have been found to do just that. Pycnogenol® has been shown to slow the progression of atherosclerotic plaques. A specialized extract of Centella asiatica helps to stabilize those plaques, reducing the risk of a life-threatening rupture. Together, these two supplements can help prevent plaque progression in those with milder atherosclerosis and reduce the development of symptoms in those with more severe disease. (From LifeExtension)

 11/01/2016   Carnosine   Carnosine is a multifunctional dipeptide made up of the amino acids beta-alanine and L-histidine.58 It is found both in food and in the human body. Long-lived cells such as nerve cells (neurons) and muscle cells (myocytes) contain high levels of carnosine.58 Muscle levels of carnosine correlate with the maximum life spans of animals. Carnosine has been shown to be an anti-glycating agent. This nutrient has the ability to suppress formation of advanced glycation end products (AGEs). Carnosine levels decline with age. Muscle levels decline 63% from age 10 to age 70, which may account for the normal age-related decline in muscle mass and function. Since carnosine acts as a pH buffer, it can keep on protecting muscle cell membranes from oxidation under the acidic conditions of muscular exertion. Carnosine enables the heart muscle to contract more efficiently through enhancement of calcium response in heart myocytes. Aging causes damage to the body’s proteins. One underlying mechanism behind this damage is glycation. Glycation involves the non-enzyme controlled cross-linking of proteins or lipids and sugars to form non-functioning structures in the body. The process of glycation can be superficially seen as wrinkled skin. Glycation is also an underlying cause of age-related neurologic, vascular, and eye problems. Carnosine is a unique dipeptide that can interfere with the glycation process.

 11/01/2016   Discordance Between Apolipoprotein B and LDL-Cholesterol in Young Adults Predicts Coronary Artery Calcification The CARDIA Study   BACKGROUND High levels of apolipoprotein B (apoB) have been shown to predict atherosclerotic cardiovascular disease (CVD) in adults even in the context of low levels of low-density lipoprotein cholesterol (LDL-C) or non–highdensity lipoprotein cholesterol (non–HDL-C). OBJECTIVESThis study aimed to quantify the associations between apoB and the discordance between apoB and LDL-C or non–HDL-C in young adults and measured coronary artery calcium (CAC) in midlife. METHODSData were derived from a multicenter cohort study of young adults recruited at ages 18 to 30 years. All participants with complete baseline CVD risk factor data, including apoB and year 25 (Y25) CAC score, were entered into this study. Presence of CAC was defined as having a positive, nonzero Agatston score as determined by computed tomography. Baseline apoB values were divided into tertiles of 4 mutually exclusive concordant/discordant groups, based on median apoB and LDL-C or non–HDL-C. RESULTSAnalysis included 2,794 participants (mean age: 253.6 years; body mass index: 24.55 kg/m 2 ; and 44.4% male). Mean lipid values were as follows: total cholesterol: 177.333.1 mg/dl; LDL-C: 109.931.1 mg/dl; non–HDL-C: 124.033.5 mg/dl; HDL-C: 5312.8 mg/dl; and apoB: 90.7 24 mg/dl; median triglycerides were 61 mg/dl. Compared with the lowest apoB tertile, higher odds of developing Y25 CAC were seen in the middle (odds ratio [OR]: 1.53) and high (OR: 2.28) tertiles based on traditional risk factor–adjusted models. High apoB and low LDL-C or non–HDL-C discordance was also associated with Y25 CAC in adjusted models (OR: 1.55 and OR: 1.45, respectively). CONCLUSIONSThese data suggest a dose–response association between apoB in young adults and the presence of midlife CAC independent of baseline traditional CVD risk factors. (J Am Coll Cardiol 2016;67:193–201) © 2016 by the American College of Cardiology Foundation.

 08/01/2016   Minimum Vitamin D Dose Inadequate For Overweight African Americans   On July 4, 2015, the journal BioMed Central Obesitypublished the results of a trial of overweight and obese African Americans that revealed a failure of the Institute of Medicine’s recommended minimum daily dose of vitamin D to elevate serum levels to a healthy range after 16 weeks of treatment.* The trial included 70 overweight or obese African Americans between the ages of 13 to 45 years with 25 hydroxyvitamin D levels of 20 ng/mL or lower. Participants were randomized to groups that received a placebo or a monthly dose equivalent to 600 IU(international units), 2,000 IU, or 4,000 IUvitamin D per day for 16 weeks. While the two higher doses were successful at restoring serum vitamin D levels to 30 ng/ mLor more at 16 weeks, those who were given the lowest dose failed to achieve this level. In contrast, participants in the 2,000 and 4,000 IUequivalent group reached a serum level of 30 ng/mLas early as eight weeks. Otimal 25-hydroxyvitamin D levels are in the range of 50-80 ng/mL. * BMC Obes. 2014 Jul 4.

 06/01/2016   Increased Vitamin C Linked To Reduced Risk Of Early Mortality   The American Journal of Clinical Nutrition published findings from researchers at the University of Copenhagen of a lower risk of cardiovascular disease and premature death in association with increases in plasma vitamin C and fruit and vegetable intake.* The investigators analyzed data from 87,030 men and women enrolled in the Copenhagen General Population Study and 10,173 participants in the Copenhagen City Heart Study. Plasma vitamin C levels were measured in 3,512 newly recruited subjects and dietary intake data was available for 83,256 subjects. Ischemic heart disease was documented in 10,123 individuals and there were 8,477 deaths over the studies’ follow-up periods. “We can see that those with the highest intake of fruit and vegetables have a 15% lower risk of developing cardiovascular disease and a 20%lower risk of early death compared with those who very rarely eat fruit and vegetables,” reported lead author Camilla Kobylecki. “At the same time, we can see that the reduced risk is related to high vitamin C concentrations in the blood from the fruit and vegetables,” Dr. Kobylecki added. * Am J Clin Nutr.2015 Jun;101(6):1135-43.

 06/01/2016   Depression Higher In Men With Borderline Testosterone Levels   An article that appeared in the Journal of Sexual Medicine reports the findings of researchers at George Washington University of a greater risk of depression and depressive symptoms in men with borderline testosterone levels.* “In an era where more and more men are being tested for ‘low T’, or lower levels of testosterone,there is very little data about the men who have borderline low testosterone levels,” observed lead researcher Michael S. Irwig, MD. Dr. Irwig and his associates analyzed data from 200 men between 20 to 77 years of age who were referred for tertiary care for testosterone levels ranging from 200 to 350 ng/dL. Patient Health Questionnaire scores were used to determine the presence of depressive symptoms. The study results showed that, compared with the general population, men with borderline testosterone levels had a significantly higher rate of depression than the general population (56% versus 23%). Analysis showed that the study participants had higher rates of obesity and lower rates of physical activity than men in the general population. Study subjects also suffered from erectile dysfunction, decreased libido, fewer morning erections, low energy, and sleep disturbances. Rates of depression were 62% for study participants in their 20s and 30s, 65%for those in their 40s, 51%for those in their 50s and 45%f or those age 60 and over. Clinicians should consider screening for depression/depressive symptoms and overweight and unhealthy lifestyle risk factors in men referred for tertiary care for potential hypogonadism,” the authors conclude. We have long urged aging men to consider maintaining total testosterone levels in the range of 700-900 ng/dL, which is where younger, healthier men normally are. * J Sex Med. 2015 Jun 30

 06/01/2016  Resveratrol, Quercetin Could Improve Safety Of Cancer Drug   Findings described in the Journal of Controlled Release suggest that the polyphenols resveratrol and quercetin could help improve the safety of Adriamycin (doxorubicin), an effective but potentially cardiotoxic chemotherapy1. Adriamycin’s mechanism of cardiotoxicity involves reactive oxygen and nitrogen species generation, a phenomenon that is reduced by free radical scavengers such as these plant derived compounds. Using a system involving polymeric micelles to improve bioavailability, Adam Alani of Oregon State University’s College of Pharmacy and associates first tested the compounds in human ovarian cancer cells and rat heart muscle cells. While Adriamycin was antagonistic toward heart cells, resveratrol and quercetin decreased the activity of caspases (protein-degrading enzymes) involved in apoptosis (programmed cell death) in these cells while not interfering with Adriamycin’s caspase activity in cancerous cells. Reactive oxygen species generated in both cell lines were reduced by resveratrol and quercetin only in the heart muscle cells. When the combo was tested in mice, resveratrol and quercetin were shown to confer full cardioprotection. 1. J Control Release. 2015 Jul 6;213:128-33

 







 

 
 



Fellow of European Society of Cardiology
 



Fellow of the Society for Cardiovascular Angiography and Interventions (SCAI)
 



Fellow American College of Chest Phyisicians
 




FELLOW GISE,Società italiana di Cardiologia Invasiva
 



Fellow ANMCO

 


 
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